Abstract: Nowadays it is highly important the security while data transmission. Since everything nowadays is transmitted through the Internet, it is very likely for our data to be taken and misused. What we have conducted is mini (minor) software in the c# language, which makes encryption of the file in .txt format, and what we will conduct in this paper is the measurement of time of encryption of different size of files with DES algorithm and AES algorithm of different CPUs by encrypting files, with which we will make comparisons between two algorithms and also make comparisons between the CPUs. Computer information technologies are evolving rapidly and are making a significant difference to our lives. Increasingly, the term "information" is used to refer to a special product that can be bought, sold, exchanged for something else, etc. The cost of information exceeds the cost of the computer system in which it is located. Therefore, there is a natural need to protect information from unauthorized access, intentional alteration, theft, destruction and other criminal activities. That is why it is important to use different crypto algorithms, such as DES, to protect user information. This is what made the topic chosen relevant. The goal of cryptography is to make it possible for two people to exchange a message in such a way that other people cannot understand the message. There is no end to the number of ways this can be done, but here we will be concerned with methods of altering the text in such a way that the recipient can undo the alteration and discover the original text (Sumitra, 2013). In this paper there is provided a comparison of DES cryptographic algorithm and AES cryptographic algorithm in different CPU. The paper is composed in three sections. The first and the second part starts with the DES and AES algorithms, continuing with the last part which deals with the results and the experiments